Paul C Marcogliese, PhD

Paul C Marcogliese, PhD

CIHR Postdoctoral Scholar Baylor College of Medicine he/him

Curriculum Vitae - Paul C Marcogliese, PhD

Present Title and Affiliation

Education

Fellowships

Recent Awards

Publications

  1. Marcogliese PC*, Deal SL*, Andrews J*, Harnish JM*, Bhavana VH, Graves HK, Jangam S, Luo X, Liu N, Bei D, Chao YH, Hull B, Lee PT, Pan H, Longley CM, Chao HT, Chung H, Haelterman NA, Kanca O, Manivannan SN, Rossetti LZ, Gerard A, Schwaibold EMC, Guerrini R, Vetro A, England E, Murali CN, Barakat TS, van Dooren MF, Wilke M, van Slegtenhorst M, Lesca G, Sabatier I, Chatron N, Brownstein CA, Madden JA, Agrawal PB, Keller R, Pavinato L, Brusco A, Rosenfeld JA, Marom R, Wangler MF#, Yamamoto S#. (2021) Drosophila functional screening of de novo variants in autism uncovers deleterious variants and facilitates discovery of rare neurodevelopmental diseases. bioRxiv 424813; doi: https://doi.org/10.1101/2020.12.30.424813.
    *Contributed equally
    #Co-corresponding

  2. Marcogliese PC*,#, Dutta D*, Sinha-Ray S, Dang NDP, Zuo Z, Wang Y, Lu D, Fazal F, Ravenscroft TA, Chung H, Kanca O, Wan J, Douine ED, Pena LDM, Yamamoto S, Nelson SF, Might M, Meyer KC, Yeo NC, Bellen HJ#. (2022) Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. Science Advances. 8(3):eabl5613.
    https://pubmed.ncbi.nlm.nih.gov/35044823/
    *Contributed equally
    #Co-corresponding

  3. Moulton MJ, Barish S, Ralhan I, Chang J, Goodman LD, Harland JG, Marcogliese PC, Johansen J, Ioannou M, Bellen HJ. (2021) Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer Disease-associated Genes. Proceedings of the National Academy of Sciences of the USA. 118(52): e2112095118. https://pubmed.ncbi.nlm.nih.gov/34949639/ Also on bioRxiv 433580; doi: https://doi.org/10.1101/2021.03.03.433580.

  4. Salazar JL, Yang S, Lin TQ, Li-Kroeger S, Marcogliese PC, Deal SL, Neely GG, Yamamoto S. (2021) TM2D genes regulate Notch signaling and neuronal function in Drosophila. PLoS Genetics 17(12):e1009962. https://pubmed.ncbi.nlm.nih.gov/34905536/ Also on bioRxiv 440660; doi: https://doi.org/10.1101/2021.04.20.440660.

  5. Rossetti LZ, Bekheirnia MR, Lewis AM, Mefford HC, Golden-Grant K, Briere LC, Sweetser DA, Walker MA, Kravets E, Stevenson DA, Bruenner G, Sebastian J, Knapo J, Rosenfeld JA, Marcogliese PC, Undiagnosed Diseases Network, Wangler MF. (2020) Missense variants in CTNNB1 can be associated with vitreoretinopathy—Seven new cases of CTNNB1‐associated neurodevelopmental disorder including a previously unreported retinal phenotype. Molecular Genetics & Genomic Medicine. e1542. https://pubmed.ncbi.nlm.nih.gov/33350591/

  6. Ravenscroft TA, Janssens J, Lee PT, Tepe B, Marcogliese PC, Makhzami S, Holmes T, Aerts S, Bellen HJ. (2020) Drosophila voltage-gated sodium channels are only expressed in active neurons and are localized to distal axonal initial segment-like domains. Journal of Neuroscience. 40:7999-8024. https://pubmed.ncbi.nlm.nih.gov/32928889/

  7. Dutta D, Briere LC, Kanca O, Marcogliese PC, Walker MA, High FA, Vanderver A, Krier J, Carmichael N, Callahan C, Taft RJ, Simons C, Helman G, The Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Sweetser DA, Bellen HJ. (2020) De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment. Human Molecular Genetics. 29(9):1568-1579. https://pubmed.ncbi.nlm.nih.gov/32356556/

  8. Chung HL, Mao X, Wang H, Park Y, Marcogliese PC, Rosenfels JA, Burrage LC, Liu P, Murdock DR, Yamamoto S, Wangler MF, Undiagnosed Diseases Network, Chao HT, Long H, Feng L, Bacino CA, Bellen HJ, Xiao B. (2020) De novo variants in CDK19 are associated with a new syndrome with intellectual disability and epileptic encephalopathy. American Journal of Human Genetics. 106:717-725. https://pubmed.ncbi.nlm.nih.gov/32330417/

  9. Chung HL, Wangler MF, Marcogliese PC, Jo J, Ravenscroft TA, Zuo Z, Duraine L, Sadeghzadeh S, Li-Kroeger D, Schmidt RE, Pestronk A, Rosenfeld JA, Burrage L, Herndon MJ, Chen S, Undiagnosed Diseases Network, Shillington A, Vawter-Lee M, Hopkin R, Rodriguez-Smith J, Henrickson M, Lee B, Moser AB, Jones RO, Watkins P, Yoo T, Mar S, Choi M, Bucelli RC, Yamamoto S, Lee HK, Prada CE, Chae JH, Vogel TP, Bellen HJ. (2020) Loss or gain of function mutations in ACOX1 cause axonal loss via different mechanisms. Neuron. 106:589-606. https://pubmed.ncbi.nlm.nih.gov/32169171/
    Recommended by F1000. Neuron 106:551-3; Best paper award 2020 – BCM-MHG

  10. Ansar M, Chung H, Al-Otaibi A, Elagabani MN, Ravenscroft TA, Paracha SA, Scholz R, TA Magid, Sarwar MT, Shah SF, Qaisar AA, Makrythanasis P, Marcogliese PC, Kamsteeg EJ, Falconnet E, Ranza E, Santoni FA, Aldhalaan H, Al-Asmari A, Faqeih EA, Ahmed J, Kornau HC, Bellen HJ, Antonarakis SE. (2019) Biallelic variants in IQSEC1 cause intellectual disability, developmental delay and short stature. American Journal of Human Genetics. 105(5):907-20. https://pubmed.ncbi.nlm.nih.gov/31607425/

  11. Guo H*, Bettella E*, Marcogliese PC*, Zhao R, Andrews JC, Nowakowski TJ, Gillentine MA, Hoekzema K, Wang T, Wu H, Jangam S, Liu C, Ni H, Willemsen MH, van Bon BW, Rinne T, Stevens SJC, Kleefstra T, Brunner HG, Ijntema H, Long M, Zhao W, Hu Z, Colson C, Nicolas RU, Schwartz C, Romano C, Castiglia L, Bottitta M, Dhar SU, Erwin DJ, Emrick L, Keren B, Afenjar A, Zhu B, Bai B, Stankiewicz P, Herman K, University of Washington Center for Mendelian Genomics, Mercimek-Andrews S, Juusola J, Wilfert AB, Jamra RA, Büttner B, Mefford HC, Muir AM, Scheffer IE, Regan BM, Malone S, Gecz J, Cobben J, Weiss JW, Waisfisz Q, Bijlsma EK, Hoffer MJV, Ruivenkamp CAL, Sartori S, Xia F, Rosenfeld JA, Bernier RA, Wangler MF, Yamamoto S, Xia K, Stegmann APA, Bellen HJ, Murgia A#, Eichler EE#. (2019) Disruptive mutations in TANC2 define a new neurodevelopmental syndrome associated with psychiatric disorders. Nature Communications. 10(1):1-7. https://pubmed.ncbi.nlm.nih.gov/31616000/
    *Contributed equally
    #Co-corresponding

  12. Shutinoski B, Hakimi M, Harmsen IE, Lunn M, Rocha J, Lengacher N, Zhou YY, Khan J, Nguyen A, Hake-Volling Q, El-Kodsi D, Li J, Alikashani A, Beauchamp C, Majithia J, Coombs K, Shimshek D, Marcogliese PC, Park DS, Rioux JD, Philpott DJ, Woulfe JM, Hayley S, Sad S, Tomlinson JJ, Brown EG, Schlossmacher MG. (2019) Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner. Science Translational Medicine. 11(511). https://pubmed.ncbi.nlm.nih.gov/31554740/

  13. Yang J, Kim KS, Iyirhiaro GO, Marcogliese PC, Callaghan SM, Qu D, Kim WJ, Slack RS, Park DS. (2019) DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress. Cell death & disease. 10(2):135. https://pubmed.ncbi.nlm.nih.gov/30755590/

  14. Lin G, Wang L, Marcogliese PC, Bellen HJ. (2019) Sphingolipids in the Pathogenesis of Parkinson's Disease and Parkinsonism. Trends in Endocrinology and Metabolism. 30(2):106-117. https://pubmed.ncbi.nlm.nih.gov/30528460/

  15. Marcogliese PC*, Shashi V*, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Martínez-Agosto JA, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K, Program for Undiagnosed Diseases (UD-PrOZA), Undiagnosed Disease Network, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ#, Pena LDM#. (2018) IRF2BPL is associated with neurological phenotypes. American Journal of Human Genetics. 103(2) 245-60. https://pubmed.ncbi.nlm.nih.gov/30057031/ Also on BioRxiv 322495; doi: https://doi.org/10.1101/322495.
    *Contributed equally
    #Co-corresponding

  16. Kim KS*, Marcogliese PC*, Yang J, Callaghan S, Resende V, Abdel-Messih E, Marras C, Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE, Canadian Lrrk2 in Inflammation Team (CLINT), Park DS. (2018) Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease. Proceedings of the National Academy of Sciences of the USA. 115(22):E5164-E5173. https://pubmed.ncbi.nlm.nih.gov/29760073/
    *Contributed equally

  17. Marcogliese PC, Wangler MF. (2018) Drosophila as a Model for Human Diseases. eLS. 1-10. https://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0005578.pub2

  18. Marcogliese PC, Abuaish S, Abdel-Messih E, Kabbach G, Seang S, Li G, Slack R, Haque EM, Venderova K, Park DS. (2017) LRRK2(I2020T) Functional Genetic Interactors that Modify Eye Degeneration and Dopaminergic Cell Loss in Drosophila. Human Molecular Genetics. 26(7) 1247-1257. https://pubmed.ncbi.nlm.nih.gov/28158614/

  19. Qu D, Hage A, Don-Carolis K, Huang E, Joselin A, Safarpour F, Marcogliese PC, Rousseaux MWC, Hewitt SJ, Huang T, Im DS, Callaghan S, Dewar-Darch D, Figeys D, Slack RS, Park DS. (2015) BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival. Journal of Biological Chemistry. 290 (51), 30441-30452. https://pubmed.ncbi.nlm.nih.gov/26538564/

  20. Sanchez G, Varaschin RK, Bueler H, Marcogliese PC, Park DS, Trudeau LE. (2014) Unimpaired striatal dopamine release in juvenile Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice. PLOS ONE. 14; 9(4) e94826. https://pubmed.ncbi.nlm.nih.gov/24733019/

  21. Rousseaux MWC, Marcogliese PC, Qu D, Hewitt SJ, Seang S, Kim RH, Slack RS, Schlossmacher MG, Lagace DC, Mak TW, Park DS. (2012) Progressive Dopaminergic Cell Loss with Unilateral-to-Bilateral Progression in a Genetic Model of Parkinson’s Disease. Proceedings of the National Academy of Sciences of the USA. 109(39): 15918-23. https://pubmed.ncbi.nlm.nih.gov/23019375/
    Highlighted in Alzheimer Research Forum, Landhuis E, “Better PD model? Dopamine Neurons Die in Genetic Cross”, 2012 Sep 14.
    Brundin P and Steiner J: F1000Prime Recommendation of [Rousseaux MWC et al., Proc Natl Acad Sci U S A 2012, 109(39):15918-23]. In F1000Prime, 27 Mar 2013; DOI: 10.3410/f.717979278.793471212. https://facultyopinions.com/prime/717979278#eval793471212

  22. Aleyasin H*, Rousseaux MWC*, Marcogliese PC, Hewitt SJ, Irrcher I, Joselin AP, Parsanejad M, Kim RH, Rizzu P, Callaghan SM, Slack RS, Mak TW, Park DS. (2010) DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proceedings of the National Academy of Sciences of the USA. 107(7): 3186-3191. https://pubmed.ncbi.nlm.nih.gov/20133695/
    *Contributed equally
    Cited as “Must Read” by F1000 Neuroscience (Thomas B, Beal M: 2010. https://facultyopinions.com/prime/1927965)

Invited Talks

  1. Drosophila in Disease Diagnosis, Mechanisms & Precision Therapy: Loss of IRF2BPL impairs neuronal maintenance via excess Wnt signaling. The Hospital for Sick Children Research Institute / University of Toronto - Seminar. 2022 Jan 15. Toronto, ON Canada.

  2. Drosophila in Disease Diagnosis, Mechanisms & Precision Therapy: Loss of IRF2BPL impairs neuronal maintenance via excess Wnt signaling. School of Medicine, Medical Sciences, & Nutrition: Research Seminar. University of Aberdeen. 2021 Dec 20. Aberdeen, Scotland, UK.

  3. Drosophila in Disease Diagnosis, Mechanisms & Precision Therapy: Loss of IRF2BPL impairs neuronal maintenance via excess Wnt signaling. Department of Medical Neuroscience: Research Seminar. Dalhousie University. 2021 Nov 18. Halifax NS, Canada.

  4. Autism-related variant annotation in Drosophila: facilitating new gene discovery. NRI Seminar Series. Texas Children’s Hospital Jan & Dan Duncan Neurological Research Institute, 2021 Nov 1, Houston, TX, USA.

  5. In vivo functional assessment of human disease variants using Drosophila. Child Seminar Series. University of Calgary & Alberta Children's Hospital Research Institute. 2021 Oct 25. Calgary AB, Canada.

  6. Drosophila in Disease Diagnosis, Mechanisms & Precision Therapy: Loss of IRF2BPL impairs neuronal maintenance via excess Wnt signaling. Department of Biochemistry and Medical Genetics: Research Seminar. University of Manitoba. 2021 Oct 12. Winnipeg MB, Canada.

  7. Loss of IRF2BPL causes neurodegeneration via excess Wnt signaling. Genetic Modifiers Workshop: Lessons from Nervous System Disorders. National Institutes of Health (Virtual). 2021 September 22, Bethesda, MD, USA.

  8. Loss of IRF2BPL causes neurodegeneration via excess Wnt signaling. Rice University Fly Meeting. 2021 July 28. Houston TX, USA.

  9. Loss of IRF2BPL causes neurodegeneration via excess Wnt signaling. University College London IHA Virtual Symposium: Neurodegeneration in Flies. 24 June 2021, London, UK.

  10. Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. Canadian Fly Meeting 2021 (Canfly 2021) (Virtual Meeting), 2021 June 21-24, University of British Columbia, Vancouver, BC, Canada.

  11. Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. 2021 Boston Area Drosophila (BAD) Meeting Neurodegeneration in Flies. Whitehead Institute for Biomedical Research (Virtual). 16 June 2021, Boston, MA, USA.

  12. Drosophila functional screening of de novo variants in autism uncovers deleterious variants and facilitates discovery of rare neurodevelopmental diseases. Genomics of Rare Disease (Virtual Conference), Wellcome Genome Campus. 22 March 2021, Hinxton, Cambridgeshire, UK.

  13. Loss of IRF2BPL causes an excess of wingless signaling associated with neuronal loss. Undiagnosed Diseases Network – Grand Rounds. 2021 Jan 14. Host: Harvard Medical School, Boston, MA, USA. (CME accredited).

  14. Loss of IRF2BPL causes an excess of wingless signaling associated with neuronal loss. NRI Dinner Seminar Series. Texas Children’s Hospital Jan & Dan Duncan Neurological Research Institute, 2020 Feb 4, Houston, TX, USA.

  15. In vivo functional assessment of putative disease variants using Drosophila: Understanding the role of IRF2BPL in neurological disease. Children’s Hospital of Eastern Ontario. 2019 June 28, Ottawa, ON, Canada.

  16. Loss-of-Function Variants in the Gene IRF2BPL are Associated with Neurological Phenotypes (Poster Preview Oral Presentation). 60th Annual Drosophila Research Conference, 2019 Mar 27-31 Dallas, TX, USA.

  17. Collaborating with clinicians in the UDN. 60th Annual Drosophila Research Conference, 2019 Mar 27-31 Dallas, TX, USA.

  18. Haploinsufficiency in IRF2BPL is associated with neurological phenotypes. Undiagnosed Diseases Network – Grand Rounds. 2018 Jun 14. Host: Harvard Medical School, Boston, MA, USA (AMA accredited).

  19. Functional screen of Autism Spectrum Disorder candidate genes using Drosophila. Rice University Fly Meeting. 21 Sep 17. Houston TX, USA.

  20. Workshop on “Parkinson’s Disease” at Encounters with Canada’s Terry Fox Canadian Youth Centre. 2016 Mar 31. Ottawa, ON, Canada.

  21. Workshop on “Parkinson’s Disease” at Encounters with Canada’s Terry Fox Canadian Youth Centre. 2016 Feb 11. Ottawa, ON, Canada.

  22. Workshop on “Parkinson’s Disease” at Encounters with Canada’s Terry Fox Canadian Youth Centre. 2015 Oct 29. Ottawa, ON, Canada.

  23. LRRK2 modulates phagocytic activity of microglia via phosphorylation of the actin-nucleating complex WAVE-2. 2015 Oct 17-21; SFN: Neuroscience 2015, Nanosymposium (Rodent models), Chicago, IL, USA.

  24. Understanding Parkinson’s Disease: LRRK2, from flies to mice. 2015 Oct 6. Parkinson Society Canada research presentation. Ottawa, ON, Canada.

  25. LRRK2 modulates phagocytic activity of microglia via phosphorylation of the actin-nucleating complex WAVE-2. 2015 Jun 29 to Jul 3; Gordon Research Conference: Parkinson Disease. New London, NH, USA.

  26. Parkinson’s Disease. Parkinson’s Society of Eastern Ontario. 2015 Apr 29. Brockville, ON, Canada.

  27. LRRK2 and Parkinson’s. Parkinson’s Society of Eastern Ontario: Learning more about Parkinson’s. 26 Jan 2015. Almonte, ON, Canada.

  28. Generation and analyses of novel preclinical models of Parkinson’s disease. 2014 Nov 14: Ontario Brain Institute (OBI) – ONDRI Workshop. London, ON.

  29. Workshop on “Parkinson’s Disease” at Encounters with Canada’s Terry Fox Canadian Youth Centre. 2014 Oct 22. Ottawa, ON, Canada.

Formal Mentoring

D. Lu - Research technician, Sep 2020 – present
S. Cho - Research technician, Jan 2020 – Jun 2020
F. Fazal – Research technician, Sep 2018 – Nov 2019
Y. Wang - Undergraduate Summer Student, Jul 2018 – Sep 2018
C. Stevens - Undergraduate Student, Aug 2017 – May 2018
M. Durham - MD/PhD Rotation student, Jan 2017 – Mar 2017
M. Gardezi - High School student, Sep 2016 – Jun 2017
F. LeBrun - Summer/Honours student, May 2014 – Jun 2016
A. Perozzo - Summer/Co-op student, May 2014 – Apr 2015
C. Wei - Summer/Honours student, May 2013 – Apr 2015
B. Philippe - Research Assistant, Sep 2013 – Aug 2014
S. Seang - Summer/Honours student, May 2011 – Apr 2013
S. Abuaish - Honours/Masters student, Sep 2010 – Aug 2012

Selected Abstracts (Primary Presenter)

  1. Marcogliese PC, Dutta D, Sinha-Ray S, Dang DPN, Zuo Z, Lu D, Fazal F, Ravenscroft TA, Chung H, Kanca O, Pena LDM, Yamamoto S, Might M, Meyer KC, Yeo NC, Bellen HJ. Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. 14th Canadian Neuroscience Meeting (Virtual Meeting), Upcoming: 2021 August 23-25, Vancouver, BC, Canada.

  2. Marcogliese PC, Deal SL, Andrews J, Harnish JM, Bhavana VH, Graves HK, Jangam S, Luo X, Liu N, Bei D, Chao YH, Hull B, Lee PT, Pan H, Longley CM, Chao HT, Chung H, Haelterman NA, Kanca O, Manivannan SN, Rossetti LZ, Gerard A, Schwaibold EMC, Guerrini R, Vetro A, England E, Murali CN, Barakat TS, van Dooren MF, Wilke M, van Slegtenhorst M, Lesca G, Sabatier I, Chatron N, Brownstein CA, Madden JA, Agrawal PB, Keller R, Pavinato L, Brusco A, Rosenfeld JA, Marom R, Wangler MF, Yamamoto S. Drosophila functional screening of de novo variants in autism uncovers deleterious variants and facilitates discovery of rare neurodevelopmental diseases. Genomics of Rare Disease (Virtual Conference), Wellcome Genome Campus. 2021 March 22, Hinxton, Cambridgeshire, UK.
    Selected for “highly commended, extended lighting talk”.

  3. Marcogliese PC, Dutta D, Zuo Z, Fazal F, Ravenscroft TA, Chung H, Kanca O, Pena LDM, Yamamoto S, Bellen HJ. Loss of IRF2BPL causes an excess of wingless signaling associated with neuronal demise. TAGC 2020. April 22-26 Washington, DC, USA.
    Cancelled due to COVID-19.

  4. Marcogliese PC, Dutta D, Fazal F, Wang Y, Spillmann RC, Chung H, Shashi V, Wangler MF, Yamamoto S, Pena LDM, Bellen HJ. Unravelling the mechanism underlying IRF2BPL in a neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures. ASHG 2019. Oct 15-19 Houston, TX, USA, Poster.

  5. Marcogliese PC. Collaborating with clinicians in the UDN. 60th Annual Drosophila Research Conference 2019 Mar 27-31 Dallas, TX, USA.

  6. Marcogliese PC, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Ortiz D, Chung H, Wang Y, Riley K, Mirzaa G, Hemelsoet D, Yamamoto S, Wangler MF, Lee B, Nelson SF, Shashi V, Pena LDM, Bellen HJ. Loss-of-Function Variants in the Gene IRF2BPL are Associated with Neurological Phenotypes. 60th Annual Drosophila Research Conference 2019 Mar 27-31 Dallas, TX, USA, Poster.
    Selected for Poster Preview Oral Presentation

  7. Marcogliese PC, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Ortiz D, Chung H, Wang Y, Riley K, Mirzaa G, Hemelsoet D, Yamamoto S, Wangler MF, Lee B, Nelson SF, Shashi V, Pena LDM, Bellen HJ. Loss-of-Function Variants in the Gene IRF2BPL are Associated with Neurological Phenotypes. Cold Springs Harbor Laboratory - Neurodegenerative Diseases: Biology & Therapeutics 2018 Nov 28 to Dec 1 Cold Spring Harbor, NY, USA, Poster.
    Selected as ‘CSHL Visitor of the Week’ - https://currentexchange.cshl.edu/blog/2018/12/visitor-of-the-week-104

  8. Marcogliese PC, Deal S, Graves HK, Chao Y, Jangam S, Bhavana VH, Luo X, Liu N, Pan H, Chao H, Lee P, Scott KL, Yamamoto S, Wangler MF. In vivo functional screening of autism candidate genes using Drosophila. 2018 Jan 18-19; Molecular and Human Genetics 2018 Research Retreat, Galveston, TX, USA, Poster

  9. Chao H*, Marcogliese PC*, Graves HK, Chao Y, Jangam S, Lagarde M, Luo X, Liu N, Manivannan SN, Saurabh S, Kanca O, Bellen HJ, Yamamoto S, Wangler MF. Identification and functional annotation of novel autism candidate genes using Drosophila studies in vivo. 2017 Mar 21; 2017 Pediatric Research Symposium – Texas Children’s Hospital, Houston, TX, USA, Poster.
    *Presented on behalf of Chao H.

  10. Marcogliese PC, Chao H, Chao Y, Graves HK, Jangam S, Manivannan SN, Lagarde M, Luo X, Liu N, Yamamoto S, Wangler MF. Functional screen of autism candidate genes using Drosophila studies in vivo. 2017 Jan 19-20; Molecular and Human Genetics 2017 Research Retreat, Galveston, TX, USA, Poster.

  11. Marcogliese PC, Kim KS, Yang J, Wei C, Abdel-Messih E, Kabbach G, Slack R, Haque EM, Venderova K, CLINT investigators, Park DS. LRRK2 modulates phagocytic activity of microglia via phosphorylation of the actin-nucleating complex WAVE-2. 2015 Oct 17-21; SFN: Neuroscience 2015, Chicago, IL, USA, Poster.
    Chosen for Nanosymposium presentation (15 min talk).

  12. Marcogliese PC, Kim KS, Wei C, Abdel-Messih E, Yang JW, Kabbach G, Slack RS, Haque EM, Venderova K, Schlossmacher MG, Hayley S, Park DS. LRRK2 modulates phagocytic activity of microglia via phosphorylation of the actin-nucleating complex WAVE-2. 2015 Jun 29 to Jul 3; Gordon Research Conference: Parkinson Disease. New London, NH, USA, Poster.
    Chosen for data blitz (1 min presentation).

  13. Marcogliese PC, Kim KS, Wei C, Yang J, Abdel-Messih E, Kabbach G, Slack R, Haque EM, Venderova K, Park DS. Understanding Parkinson’s disease: LRRK2 modulates the phagocytic activity of microglia via stabilization of WAVE2. 2015 June 12; Brain Health Research Day, Ottawa, Canada, Poster.
    Awarded Runner-up for Trainee PhD Presentation award.

  14. Marcogliese PC, Abuaish S, Abdel-Messih E, Kabbach G, Seang S, Li G, Slack R, Haque EM, Venderova K, Park DS. Functional LRRK2 genetic interaction screen in Drosophila. 2013 October 3; World Parkinson Congress, Montreal, Canada, Poster.

  15. Marcogliese PC, Abuaish S, Abdel-Messih E, Kabbach G, Seang S, Li G, Slack R, Haque EM, Venderova K, Park DS. Understanding Parkinson’s Disease: Elucidating LRRK2 Genetic Interactors using Drosophila. 2013 March 6-10; AD/PD 2013, Florence, Italy, Poster.

  16. Marcogliese PC, Abuaish S, Abdel-Messih E, Kabbach G, Li G, Slack R, Haque EM, Venderova K, Park DS. Genetic Interactors of Parkinson’s gene LRRK2 using Drosophila. 2012 March 21; Cell Death Pathways: Beyond Apoptosis, Banff, AB, Poster.

  17. Marcogliese PC, Li G, Abuaish S, Venderova K, Kabbach G, Abdel-Messih E, Slack R, Haque EM, Park DS. Interactions of PD related gene LRRK2; Screen in Drosophila. 2011 June 17; Brain Health Research Day, Ottawa, ON, Poster.

Recent Academic Service

Skills (include but not limited to:)

Academic Memberships

Canadian Association for Neuroscience, Genetics Society of America, American Association for the Advancement of Science, American Society of Human Genetics, Undiagnosed Diseases Network, Let’s Talk Science, Parkinson’s Research Consortium (Student Member), Society for Neuroscience, Bond Journal Club (Co-Founder), Pass The Baton for Parkinson’s, CMM/NSC Student Council (Neuroscience Rep. 2010 - 2012), Toastmasters International (Carleton Toastmasters)